Doug (Jack Black) and Griff (Paul Rudd) have been best friends since they were kids, and have always dreamed of remaking their all-time favorite movie: the cinematic "classic" Anaconda. When a midlife crisis pushes them to finally go for it, they head deep into the Amazon to start filming. But things get real when an actual giant anaconda appears, turning their comically chaotic movie set into a deadly situation. The movie they’re dying to make? It might just get them killed.